ISSN: ISSN 2472-0429

Avances en la prevención del cáncer

Acceso abierto

Nuestro grupo organiza más de 3000 Series de conferencias Eventos cada año en EE. UU., Europa y América. Asia con el apoyo de 1.000 sociedades científicas más y publica más de 700 Acceso abierto Revistas que contienen más de 50.000 personalidades eminentes, científicos de renombre como miembros del consejo editorial.

Revistas de acceso abierto que ganan más lectores y citas
700 revistas y 15 000 000 de lectores Cada revista obtiene más de 25 000 lectores

Abstracto

Calcium-activated potassium channels as potential early markers of cervical cancer

Javier Camacho

Cervical cancer is a major cause of cancer death in women in developing countries. Thus, novel early markers
and therapeutic targets are urgently needed. Ion channels have gained great interest as tumor markers for different
malignancies including cervical cancer. Actually, some years ago, we suggested Kv10.1 channel as cervical
cancer early marker. Here, we studied the expression of another potassium channel, namely, the calcium-activated
potassium channel KCa1.1 (KCNMA1) in cervical cancer models. Transgenic mice expressing the E7 oncogene of
human papilloma virus and non-transgenic mice were treated with estradiol pellets during three or six months to
induce cervical lesions. Human biopsies from patients with either noncancerous, low- or high-grade intra-epithelium
lesions or cervical cancer were also studied. mRNA and protein expression were studied by real-time RT-PCR and
immunochemistry, respectively. Cervical dysplasia and cervical cancer were observed only in the transgenic mice
treated with estradiol for three and six months, respectively. Estradiol treatment increased KCa1.1 mRNA and protein
expression in both transgenic and non-transgenic mice. However, the highest levels were observed in the transgenic
mice with cervical cancer. Human biopsies form non-cancerous cervix did not display KCa1.1 protein expression.
However, increased KCa1.1 protein expression was observed in the rest of the human biopsies, we observed that the
higher the grade of the lesion, the stronger the KCa1.1 immune staining. These results suggest KCa1.1 channel as
potential early cervical cancer marker.

Descargo de responsabilidad: este resumen se tradujo utilizando herramientas de inteligencia artificial y aún no ha sido revisado ni verificado.