Revista de enfermedad de Alzheimer y parkinsonismo

Abstracto

Epidemiology and Genetics of Alzheimer's Disease

Povova Jana, Sery Omar, Tomaskova Hana, Vargova Lydia, Ambroz Petr, Luzny Jan, Pohlidalova Anna and Janout Vladimir

Alzheimer’s disease (AD) is the most common form of dementia. It is a degenerative and incurable terminal disease. AD accounts for 75% of all forms of dementia all over the world. Its etiology is still unknown. Numerous risk factors of AD have already been discovered. In this paper, some preliminary results are presented. The results suggested that persons with AD often had cardiovascular disease in their history. Conversely, they did not have diabetes mellitus, hypertension and cerebrovascular disease. A relationship between the ApoE4 allele and a higher risk of AD was found (OR 2.52). Among ACE genotypes, the I allele increases the risk of AD, and in this pilot sample, the II genotype showed the OR on the borderline of significance (OR 1.43;95% CI 0.97-2.12).