Medicina Tradicional y Naturopatía Clínica

Abstracto

Exploration of the Hematological Profile of Male Sprague-Dawley Rats after Chronic Administration of an Ayurvedic Formulation Punarnavasava (PRV) Used in Ascites Treatment

Md Atikur Rahman, Mohammad Tohidul Amin, Md. Abdul Aziz, Kaniz Fatema, Palash karmakar, Niloy Sen and M Shahabuddin Kabir Choudhuri

Punarnavasava (PRV) is a classical Ayurvedic preparation and is very popular in rural areas due to its usage in the treatment of ascites. This study was conducted to explore the hemotoxicological effect of PRV after chronic administrations for 45 days to male Sprague-Dawley rats. After the observations, there were statistically significant changes in Basophil and Lymphocyte count (p=0.020 and p=0.032 respectively) but showed negligible changes for other hematological parameters like RBC, Hemoglobin, Hematocrit, Mean Corpuscular Volume (MCV), Mean Corpuscular Hemoglobin (MCH), Mean Corpuscular Hemoglobin Concentration (MCHC), Erythrocyte sedimentation rate (ESR), etc. From these results, it can be concluded that PRV is less hemotoxic at higher doses and thus can be recommended to use safely in the treatment of ascites.