Nuestro grupo organiza más de 3000 Series de conferencias Eventos cada año en EE. UU., Europa y América. Asia con el apoyo de 1.000 sociedades científicas más y publica más de 700 Acceso abierto Revistas que contienen más de 50.000 personalidades eminentes, científicos de renombre como miembros del consejo editorial.
Revistas de acceso abierto que ganan más lectores y citas
700 revistas y 15 000 000 de lectores Cada revista obtiene más de 25 000 lectores
Romero R, Salazar Alcalá E, Cedeño N and Fernández-Mestre M
Objective: Based on that the association of the ε4 allele of the APOE gene with the development of late-onset AD is one of the strongest and that TLR4 has been involved in AD pathogenesis. The aim of the present work was to study the role of rs4986791 polymorphism of the TLR4 gene in the development of AD and correlate any such association with the presence of allele ε4 of the APOE gene. Methods: We included 161 unrelated Venezuelan subjects classified as either AD patients (n=61) or healthy individuals (n=100). Polymorphisms of TLR4 and APOE genes were identified with PCR-SSP and PCR-RFLP, respectively.
Results: The rs4986791 polymorphism does not appear to be related to AD, although the presence of the CC genotype and the C allele apparently confers three times higher risk of developing AD. Finally, positive and negative associations among the combinations TLR4 /APOE genes and AD were observed.
Conclusion: The results suggest the absence of any association between rs4986791 polymorphism of TLR4 gene and susceptibility to AD and the association of the ε4 allele of the APOE gene with the development of this pathology was confirmed.