Revista internacional de investigación y desarrollo en farmacia y ciencias biológicas

Abstracto

DETERMINATION OF MAJOR ORGANIC CONSTITUENTS IN FK 506 TREATED TISSUES OF ALBINO RATS

Chittibabu. B, Ayya Raju. M

FK 506 is an immunosuppressive agent and highly stable 11-amino acid cyclic polypeptide. Present study demonstrated that FK 506 at the dose and time periods (1 mg / kg over 7 or 28 days impair the rat tissue based organic constituents, FK 506 depleted the rat tissue total protein, carbohydrate, lipid and glycogen contents of all rat tissues selected for the present study and whereas the same FK 506 treatment enhanced the rat tissues FAA and FFA contents: compared to saline treated rat control tissues. The overall data it is evident that FK 506 administration in the present study impairs the overall general metabolism of rat tissues.