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Jes Paul*
In this advanced world, one of the major health problems the world facing is obesity. This is a worldwide problem which can lead to the occurrence of many serious illnesses like diabetes and heart diseases. It is now crystal clear that obesity not only perturbs lipid and glucose homeostasis but also it damages the pathways of the body. As the excess adiposity can integrate many pathways it will result in immune responses in the body like inflammation. The need to understand how the body react to such alterations in its metabolic functions, resulting in chronic autoimmune diseases like diabetes is very important. A deep and clear understanding of these responses is important to fully aware and treating chronic metabolic diseases.