Revista internacional de investigación y desarrollo en farmacia y ciencias biológicas

Abstracto

SPECTROPHOTOMETRIC METHOD FOR THE DETRMAINATION OF BETA NITEDINE IN PHAMRACETUTICAL FORMULATION BY INDIRECT OXIDIMETRIC METHOD

Sachin Subhasharao Bangade

A sample and sensitive spectrophotometric method in visible region has been developed for the determination of Beta- Nitedine . The reaction in the method is a stoichiometric oxidation when the drug is treated with an excess of oxidant N-Bromosuccinimide [NBS] .The unreacted oxidant is then estimated colorimetrically by using an oxidisable dye, Celestine blue [CB], Beer’s law limits for method is10-100μg/ml. No interference applicability of the method was examined by analyzing tablets coating Beta-Nitedine.